Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.
Article| December 01 1976
Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids.
J D Vassalli
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1976) 144 (6): 1689–1694.
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J Hamilton, J D Vassalli, E Reich; Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids.. J Exp Med 1 December 1976; 144 (6): 1689–1694. doi: https://doi.org/10.1084/jem.144.6.1689
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