Evidence is presented to support the contention that IgM demonstrable by surface immunofluorescent staining on H-2-activated T cells represents specifically adsorbed B-cell-derived alloantibody. T cells activated to H-2 determinants expressed surface IgM only when the progenitor cell populations contained B lymphocytes. IgM was not detected on T cells activated to determinants which fail to stimulate alloantibody production (e.g., M-locus determinants). In addition, IgM-negative H-2 activated T cells (derived from B-cell-depleted lymphoid cells), unlike M-locus-activated T cells, adsorbed IgM in a specific manner when incubated in vitro with "early bleed" antisera raised against the activating H-2 determinants.
Article| February 01 1976
Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1976) 143 (2): 444–449.
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L Hudson, J Sprent; Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes.. J Exp Med 1 February 1976; 143 (2): 444–449. doi: https://doi.org/10.1084/jem.143.2.444
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