Congenic mouse strains differing only at genes within the H-2 complex were found to have virus-specific cytotoxic effector cells in their spleens during or after recovery from Friend leukemia virus-induced splenomegaly. These effector cells were theta-positive T lymphocytes which functioned in vitro without help or inhibition by B lymphocytes or glass-adherent cells. The antigenic specificities recognized by the effector cells were viral-induced cellular antigens apparently different from those identified by serological techniques.
Article| January 01 1976
Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1976) 143 (1): 85–99.
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B Chesebro, K Wehrly; Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity.. J Exp Med 1 January 1976; 143 (1): 85–99. doi: https://doi.org/10.1084/jem.143.1.85
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