Experimental amyloidosis in mice can be induced by repeated injections of casein. It has now been demonstrated that casein induces strong polyclonal antibody synthesis in mouse B spleen lymphocytes. This effect is much more pronounced in spleen cells from anyloid-susceptible mice (CBA/J) than amyloid-resistant mice (A/J). It is suggested that amyloidosis can be due in some instances to a constant exposure for molecules which induce polyclonal B-cell activation.
Article| December 01 1975
Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1975) 142 (6): 1564–1569.
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S Britton; Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control.. J Exp Med 1 December 1975; 142 (6): 1564–1569. doi: https://doi.org/10.1084/jem.142.6.1564
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