Normal human fibroblasts contain a cell type-specific glycoprotein antigen (SF) that is known to be slowly shed into the medium and to be present also in human serum. Immunofluorescence with anti-SF antibodies showed that SF antigen has a highly nonrandom fibrillar distribution in surface of normal fibroblasts. Simian virus 40-transformed fibroblasts also produced the SF antigen, as shown by radioimmunoassay or immunodiffusion tests, but it was not retained by the surface of these cells. This creates a major difference between the surfaces of normal and malignant cells.
Article| August 01 1975
Fibroblast surface antigen produced but not retained by virus-transformed human cells.
Online Issn: 1540-9538
Print Issn: 0022-1007
J Exp Med (1975) 142 (2): 530–535.
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A Vaheri, E Ruoslahti; Fibroblast surface antigen produced but not retained by virus-transformed human cells.. J Exp Med 1 August 1975; 142 (2): 530–535. doi: https://doi.org/10.1084/jem.142.2.530
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