A study of the composition and functional properties of spleen cells from the immune deficient CBA/HN mice and their F1 progeny is reported. While abnormalities were seen in both the numbers and function of thymus-independent (B) lymphocytes, all studies involving thymus-dependent (T) lymphocytes were normal. The X-linked nature of the immune defect in these mice was therefore attributed to abnormal or absent B lymphocytes. The possible nature of this defect and the similarity of the immune defect in these mice to certain human X-linked immunodeficiency diseases are discussed.
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells.
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I Scher, A Ahmed, D M Strong, A D Steinberg, W E Paul; X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells.. J Exp Med 1 April 1975; 141 (4): 788–803. doi: https://doi.org/10.1084/jem.141.4.788
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