CLONAL MEMORY I. TIME-COURSE OF PROLIFERATION OF B-MEMORY CELLS

McMichael , A. J.; Williamson , A. R.

doi:10.1084/jem.139.5.1361

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Brief Definitive Report| May 01 1974

CLONAL MEMORY : I. TIME-COURSE OF PROLIFERATION OF B-MEMORY CELLS

A. J. McMichael,

A. J. McMichael

From the National Institute for Medical Research, Mill Hill, London NW7 1AA England

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A. R. Williamson

From the National Institute for Medical Research, Mill Hill, London NW7 1AA England

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Author and Article Information

A. J. McMichael

From the National Institute for Medical Research, Mill Hill, London NW7 1AA England

A. R. Williamson

From the National Institute for Medical Research, Mill Hill, London NW7 1AA England

Received: February 19 1974

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1974

J Exp Med (1974) 139 (5): 1361–1367.

https://doi.org/10.1084/jem.139.5.1361

A single clone of B cells producing anti-DNP antibody recognizable by the isoelectric-focusing spectrum has been used, in a double transfer system, to study clonal memory. Trasnsferable B memory develops between 4 and 7 days after the first transfer with antigen. B-memory cells thus proliferate before or concomitantly with antibody-forming cells.

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