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Volume 139, Issue 5
1 May 1974
Journal of Experimental Medicine Cover Image for Volume 139, Issue 5
Article| May 01 1974

IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE

A. J. Garvin,
A. J. Garvin
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
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S. S. Spicer,
S. S. Spicer
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
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R. T. Parmley,
R. T. Parmley
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
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A. M. Munster
A. M. Munster
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
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Author and Article Information
A. J. Garvin
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
S. S. Spicer
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
R. T. Parmley
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
A. M. Munster
From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401
Received: January 29 1974
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 139 (5): 1077–1083.
https://doi.org/10.1084/jem.139.5.1077
Article history
Received:
January 29 1974

Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.

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Copyright © 1974 by The Rockefeller University Press
1974
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