Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.
IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
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A. J. Garvin, S. S. Spicer, R. T. Parmley, A. M. Munster; IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE . J Exp Med 1 May 1974; 139 (5): 1077–1083. doi: https://doi.org/10.1084/jem.139.5.1077
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