Immunoglobulins and complement are deposited in the glomerular mesangium of rats with progressive glomerulosclerosis secondary to chemically induced diabetes mellitus. Isotransplantation of a kidney from a rat diabetic for 6 mo into a normal recipient results within 2 mo in the disappearance of IgG, IgM, and ß1C from the mesangium and arrest or reversal of the light microscopic glomerular lesions. Kidneys isotransplanted from normal donors into diabetic rats developed mesangial matrix thickening and deposition of IgG, IgM) and ß1C in the mesangium. No glomerular changes occur upon transplantation of a normal kidney into a normal rat. These findings indicate that diabetic glomerular changes in the rat are reversible and are secondary to the diabetic state rather than to the inducing agent.
RENAL TRANSPLANTATION IN DIABETES MELLITUS IN RATS
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Chue Shue Lee, S. Michael Mauer, David M. Brown, David E. R. Sutherland, Alfred F. Michael, John S. Najarian; RENAL TRANSPLANTATION IN DIABETES MELLITUS IN RATS . J Exp Med 1 April 1974; 139 (4): 793–800. doi: https://doi.org/10.1084/jem.139.4.793
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