INFLUENCE OF ERYTHROCYTE MEMBRANE COMPONENTS ON MALARIA MEROZOITE INVASION

Miller , Louis H.; Dvorak , James A.; Shiroishi , Tsugiye; Durocher , John R.

doi:10.1084/jem.138.6.1597

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Brief Definitive Report| December 01 1973

INFLUENCE OF ERYTHROCYTE MEMBRANE COMPONENTS ON MALARIA MEROZOITE INVASION

Louis H. Miller,

Louis H. Miller

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

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James A. Dvorak,

James A. Dvorak

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

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Tsugiye Shiroishi,

Tsugiye Shiroishi

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

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John R. Durocher

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

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Author and Article Information

Louis H. Miller

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

James A. Dvorak

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Tsugiye Shiroishi

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

John R. Durocher

From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Received: September 05 1973

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1973

J Exp Med (1973) 138 (6): 1597–1601.

https://doi.org/10.1084/jem.138.6.1597

Chymotrypsin- and Pronase-treated human erythrocytes were refractory to invasion by P. knowlesi merozoites; invasion was not inhibited by trypsin or neurammidase treatment. These data implicate a surface protein other than sialoglycoprotein as the receptor site for merozoites. Invasion of rhesus erythrocytes was unaffected by pretreatment with these enzymes. Differences in membrane structure of erythrocytes from various species may explain the absence of an enzyme effect on rhesus erythrocytes.

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