The functional attributes of minor subpopulations of mouse thymus cells derived by bovine serum albumin density gradient centrifugation, cortisone treatment, or selective depletion by anti-TL or anti-θ treatment have been examined. A subpopulation derived in each fashion contains the cells required to evoke graft-versus-host reactions in neonatal F1 hybrid recipients and to be stimulated by alloantigens in vitro in one-way mixed lymphocyte cultures and by phytohemagglutinin. The functions of this subpopulation are abrogated by treatment with anti-H-2 plus complement and by high concentrations of anti-θ. A tentative ordering of the various thymus cell subpopulations, on the basis of these and other data, is described.
IMMUNOLOGIC PROPERTIES OF MOUSE THYMUS CELLS : IDENTIFICATION OF T CELL FUNCTIONS WITHIN A MINOR, LOW-DENSITY SUBPOPULATION
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Susumu Konda, Yoshinobu Nakao, Richard T. Smith; IMMUNOLOGIC PROPERTIES OF MOUSE THYMUS CELLS : IDENTIFICATION OF T CELL FUNCTIONS WITHIN A MINOR, LOW-DENSITY SUBPOPULATION . J Exp Med 1 December 1972; 136 (6): 1461–1477. doi: https://doi.org/10.1084/jem.136.6.1461
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