VARIATIONS IN THE RESPONSES OF C57BL/10J AND A/J MICE TO SHEEP RED BLOOD CELLS : I. SEROLOGICAL CHARACTERIZATION AND GENETIC ANALYSIS

In response to repeated injections of sheep red blood cells, C57BL/10J mice produce predominantly 19S antibody in increasingly higher amounts, while A/J mice initially produce 19S antibody and then switch to produce increasing 7S antibody titers. In an F₁ generation all mice responded like the C57BL/10J mice. Backcross data implied genetic control involving at least three loci.