The immunogenicity of the haplotypes in 30 families was measured by survival of skin grafts between selected paired family members. These families were genotyped for HL-A using 57 selected cytotoxic alloantisera defining HL-A 1–12 as well as other nondefined specificities. Mixed leukocyte reactions were also studied in this series and the correlations between the mixed leukocyte reactions with skin graft survival times, individual HL-A specificities, and the number of incompatible HL-A alleles are reported. Comments concerning the interpretation and quantitation of the mixed leukocyte reactions are discussed.
THE IMMUNOGENICITY OF HUMAN HL-A HAPLOTYPES AS MEASURED BY SKIN GRAFT SURVIVAL TIMES AND MIXED LEUKOCYTE REACTIONS
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H. F. Seigler, F. E. Ward, D. B. Amos, M. B. Phaup, D. L. Stickel; THE IMMUNOGENICITY OF HUMAN HL-A HAPLOTYPES AS MEASURED BY SKIN GRAFT SURVIVAL TIMES AND MIXED LEUKOCYTE REACTIONS . J Exp Med 1 March 1971; 133 (3): 411–423. doi: https://doi.org/10.1084/jem.133.3.411
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