The following peptides have previously been shown to bind specifically with antibodies to TMVP: (a) An eicosapeptide representing residues 93–112 of TMVP and having the sequence Ileu-Ileu-Glu-Val-Glu-AspNH2-GluNH2-Ala-AspNH2-Pro-Thr-Thr-Ala-Glu-Thr-Leu-Asp-Ala-Thr-Arg. (b) Its C-terminal decapeptide. (c) Its C-terminal pentapeptide. (d) N-octanoyl-C-terminal-tripeptide. (e) (Lys)4-C-terminal-pentapeptide. (f) (Lys)7 C-terminal-pentapeptide. The present communication deals with the investigation of several parameters of the immunological activity of the peptides. The results show that none of the peptides tested were immunogenic in guinea pigs, nor did they stimulate the incorporation of 14C-thymidine by spleen cells derived from TMVP-primed animals. Results also showed that all of the peptides tested could elicit specific delayed and immediate skin reactions in TMVP-sensitized guinea pigs, and furthermore, that the peptides could specifically inhibit the migration of peritoneal exudate cells derived from these animals. The elicitation of delayed skin reactions and the ability to inhibit migration of peritoneal exudate cells were independent of carrier specificity.
Skip Nav Destination
Article navigation
1 January 1970
Article|
January 01 1970
STUDIES ON THE IMMUNE RESPONSE TO A CHARACTERIZED ANTIGENIC DETERMINANT OF THE TOBACCO MOSAIC VIRUS PROTEIN
Lynn Spitler,
Lynn Spitler
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Search for other works by this author on:
E. Benjamini,
E. Benjamini
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Search for other works by this author on:
Janis D. Young,
Janis D. Young
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Search for other works by this author on:
Harvey Kaplan,
Harvey Kaplan
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Search for other works by this author on:
H. H. Fudenberg
H. H. Fudenberg
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Search for other works by this author on:
Lynn Spitler
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
E. Benjamini
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Janis D. Young
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Harvey Kaplan
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
H. H. Fudenberg
From the Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California 94122, the Laboratory of Medical Entomology, Kaiser Foundation Research Institute, and the Allergy Research Division, Allergy Department, Kaiser Foundation Hospital, San Francisco, California 94115
Received:
September 09 1969
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1970 by The Rockefeller University Press
1970
J Exp Med (1970) 131 (1): 133–148.
Article history
Received:
September 09 1969
Citation
Lynn Spitler, E. Benjamini, Janis D. Young, Harvey Kaplan, H. H. Fudenberg; STUDIES ON THE IMMUNE RESPONSE TO A CHARACTERIZED ANTIGENIC DETERMINANT OF THE TOBACCO MOSAIC VIRUS PROTEIN . J Exp Med 1 January 1970; 131 (1): 133–148. doi: https://doi.org/10.1084/jem.131.1.133
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionSuggested Content
Email alerts
Advertisement
