CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES

Shulman , Herbert J.; Meyer , Karl

doi:10.1084/jem.128.6.1353

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Article| December 01 1968

CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES

Herbert J. Shulman,

Herbert J. Shulman

From The Department of Medicine, Columbia University College of Physicians and Surgeons, the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York 10032, and the Belfer Graduate School of Science, Yeshiva University, New York, New York 10033

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Karl Meyer

From The Department of Medicine, Columbia University College of Physicians and Surgeons, the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York 10032, and the Belfer Graduate School of Science, Yeshiva University, New York, New York 10033

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Author and Article Information

Herbert J. Shulman

From The Department of Medicine, Columbia University College of Physicians and Surgeons, the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York 10032, and the Belfer Graduate School of Science, Yeshiva University, New York, New York 10033

Karl Meyer

From The Department of Medicine, Columbia University College of Physicians and Surgeons, the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital, New York 10032, and the Belfer Graduate School of Science, Yeshiva University, New York, New York 10033

Received: August 02 1968

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1968

J Exp Med (1968) 128 (6): 1353–1362.

https://doi.org/10.1084/jem.128.6.1353

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate.

Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate.

These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented.

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CELLULAR DIFFERENTIATION AND THE AGING PROCESS IN CARTILAGINOUS TISSUES : MUCOPOLYSACCHARIDE SYNTHESIS IN CELL CULTURES OF CHONDROCYTES

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