IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE

Hirsch , Martin S.; Murphy , Frederick A.; Hicklin , Martin D.

doi:10.1084/jem.127.4.757

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Article| April 01 1968

IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE

Martin S. Hirsch,

Martin S. Hirsch

From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, Atlanta, Georgia 30333

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Frederick A. Murphy,

Frederick A. Murphy

From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, Atlanta, Georgia 30333

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Martin D. Hicklin

From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, Atlanta, Georgia 30333

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Author and Article Information

Martin S. Hirsch

From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, Atlanta, Georgia 30333

Frederick A. Murphy

From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, Atlanta, Georgia 30333

Martin D. Hicklin

From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, Atlanta, Georgia 30333

Received: December 17 1967

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1968

J Exp Med (1968) 127 (4): 757–766.

https://doi.org/10.1084/jem.127.4.757

Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.

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IMMUNOPATHOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTION OF NEWBORN MICE : ANTITHYMOCYTE SERUM EFFECTS ON GLOMERULONEPHROTIS AND WASTING DISEASE

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