THE EFFECT OF HISTOCOMPATIBILITY-2 TYPE ON RESPONSE TO THE FRIEND LEUKEMIA VIRUS IN MICE

Two types of quantitative response to the F-B strain of Friend virus in segregating generations of a cross involving a susceptible (DBA/2 or BALB/c; H-2²) and a resistant (C57BL/6; H-2^b) mouse strain show a marked correlation with the H-2 type of the mice. Essential susceptibility, as determined by the splenomegalic response to high virus doses, is controlled by a single pair of alleles which segregates independently with respect to the H-2 locus. However, relative susceptibility, as determined by the incidence of the splenomegalic response at moderate or low levels of virus dosage, is significantly greater among mice homozygous or heterozygous for the H-2^d allele than among H-2^b homozygotes in these populations. In addition, the incidence of recovery from splenomegaly induced by a given level of virus dosage is significantly greater in H-2^b homozygotes than in segregants of other H-2 types among their littermates. Possible mechanisms responsible for these effects are discussed.