STUDIES ON ARTIFICIAL ANTIGENS : II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-α-AMINO ACIDS

An effort was made to immunize guinea pigs with arsanilic acid conjugates of copolymers of D- and L-α-amino acids; ASD-GAT and ASL-GAT. An immune response was observed only in the case of ASL-GAT. Antibodies specific for the arsanilic acid hapten were produced which could also react with ASD-GAT or ASGPA. These findings indicate that the proper metabolism of the antigen may be essential to the induction of the immune response.