Rabbits made granulocytopenic with nitrogen mustard have been shown to generate serum endogenous pyrogen when given a fever-producing dose of bacterial endotoxin. This finding is in accord with the hypothesis that endogenous pyrogen plays a central role in the pathogenesis of endotoxin fever. The fact that leucopenic animals produce less serum-endogenous pyrogen than normal animals given the same dose of endotoxin has also been confirmed and suggests that polymorphonuclear leucocytes constitute a major source of the endogenous pyrogen which is demonstrable in the circulation during endotoxin fever.
STUDIES ON THE PATHOGENESIS OF FEVER : VIII. FURTHER OBSERVATIONS ON THE ROLE OF ENDOGENOUS PYROGEN IN ENDOTOXIN FEVER
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Samuel M. Gillman, Donald L. Bornstein, W. Barry Wood; STUDIES ON THE PATHOGENESIS OF FEVER : VIII. FURTHER OBSERVATIONS ON THE ROLE OF ENDOGENOUS PYROGEN IN ENDOTOXIN FEVER . J Exp Med 1 November 1961; 114 (5): 729–739. doi: https://doi.org/10.1084/jem.114.5.729
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