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Volume 114, Issue 2
1 August 1961
Journal of Experimental Medicine Cover Image for Volume 114, Issue 2
Article| August 01 1961

THE EFFECT OF AMINOMETHYLPTEROYLGLUTAMIC ACID ON THE DEVELOPMENT OF SKIN HYPERSENSITIVITY AND ON ANTIBODY FORMATION IN GUINEA PIGS

Robert M. Friedman,
Robert M. Friedman
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Viral Immunology, Bethesda
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Charles E. Buckler,
Charles E. Buckler
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Viral Immunology, Bethesda
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Samuel Baron
Samuel Baron
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Viral Immunology, Bethesda
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Author and Article Information
Robert M. Friedman
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Viral Immunology, Bethesda
Charles E. Buckler
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Viral Immunology, Bethesda
Samuel Baron
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Viral Immunology, Bethesda
Received: March 26 1961
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1961, by The Rockefeller Institute
1961
J Exp Med (1961) 114 (2): 173–183.
https://doi.org/10.1084/jem.114.2.173
Article history
Received:
March 26 1961

1. In guinea pigs, aminomethylpteroylglutamic acid (methotrexate) is capable of blocking the development of delayed skin hypersensitivity, the primary antibody response, and the specific febrile response to ovalbumin and diphtheria toxoid. The primary antibody response is more easily inhibited than is the development of delayed skin hypersensitivity.

2. The effect of methotrexate on immunologic responses depended upon the dose of methotrexate employed and the strength of the antigenic stimulus.

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Copyright, 1961, by The Rockefeller Institute
1961
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