Estradiol in large amounts reduces the incorporation of radioactive sulfate into cartilage and aortas of rats.

This reduction becomes apparent within 3 days for cartilage and 3 weeks for aorta.

The effect is not mediated through suppression of testosterone secretion and the hypophysis is not necessary for the effect to be demonstrated.

The thoracic segment of aortas from normal rats incorporates more sulfate than does the abdominal segment and this difference is reduced following the administration of estradiol.

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