The acute form of hereditary premature senescence in 79 rabbits, among which the 20th generation of the condition was represented, has been described. The manifestations did not differ in kind from those previously described in connection with the chronic form (1) of the complex but their degree and, in particular, the severity and the rate of progression of systemic degeneration were much greater. The rabbits either did not survive to 2 years 6 months, of age or their physical condition had become critical by this time. A senile appearance, largely due to deteriorative changes of the coat, was frequently observed.
The essential nature of the senescence condition was obviously a degeneration and one in which vital mechanisms essential to the maintenance of health were involved.