The sequential cytological changes which develop in tissue culture cells infected with adenovirus types 5 and 7 are described and compared with those produced by adenovirus types 1, 2, 3, and 4. The evidence that is presented indicates that types 1, 2, and 5 belong to one major subdivision of the adenovirus group and types 3, 4, and 7 to another. That the host cell nucleus is the principal site of adenovirus synthesis has been confirmed by fluorescent antibody studies. They have demonstrated the occurrence of type-specific adenovirus antigen in the characteristic intranuclear inclusions and other virus-induced structures reported to contain virus-like particles or shown by electronmicroscopy.
SEQUENTIAL CELLULAR CHANGES PRODUCED BY TYPES 5 AND 7 ADENOVIRUSES IN HELA CELLS AND IN HUMAN AMNIOTIC CELLS : CYTOLOGICAL STUDIES AIDED BY FLUORESCEIN-LABELLED ANTIBODY
- Views Icon Views
- PDF LinkPDF
- Share Icon Share
- Search Site
Georgiana S. Boyer, Floyd W. Denny, Harold S. Ginsberg; SEQUENTIAL CELLULAR CHANGES PRODUCED BY TYPES 5 AND 7 ADENOVIRUSES IN HELA CELLS AND IN HUMAN AMNIOTIC CELLS : CYTOLOGICAL STUDIES AIDED BY FLUORESCEIN-LABELLED ANTIBODY . J Exp Med 1 November 1959; 110 (5): 827–844. doi: https://doi.org/10.1084/jem.110.5.827
Download citation file: