Reinjection of antigen into immunized rabbits usually results in an immediate increase of circulating antibody-antigen complex. This immediate formation of complex seems to depend upon the presence of non-precipitating antibody before reinjection. The complex disappears by the 2nd day after reinjection and reappears between the 4th to 7th day. This is earlier than its first appearance after a primary injection and may indicate an anamnestic response of the non-precipitating antibody responsible for the formation of circulating antibody-antigen complex.
STUDIES ON NON-PRECIPITATING ANTIBODY : II. CIRCULATING ANTIBODY-ANTIGEN COMPLEX FOLLOWING REPEAT INJECTIONS OF ANTIGEN
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Ludwig A. Sternberger; STUDIES ON NON-PRECIPITATING ANTIBODY : II. CIRCULATING ANTIBODY-ANTIGEN COMPLEX FOLLOWING REPEAT INJECTIONS OF ANTIGEN . J Exp Med 1 May 1956; 103 (5): 545–552. doi: https://doi.org/10.1084/jem.103.5.545
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