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Volume 102, Issue 6
1 December 1955
Journal of Experimental Medicine Cover Image for Volume 102, Issue 6
Article| December 01 1955

A METHOD FOR COUPLING PROTEIN ANTIGENS TO ERYTHROCYTES : II. USE OF THE METHOD IN THE DIAGNOSIS OF TUBERCULOSIS

Leon R. Cole,
Leon R. Cole
From the Departments of Medicine, Peter Bent Brigham Hospital, and Harvard University Medical School, and the Departments of Medicine, Boston City Hospital, and Boston University Medical School, Boston
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J. Jay Matloff,
J. Jay Matloff
From the Departments of Medicine, Peter Bent Brigham Hospital, and Harvard University Medical School, and the Departments of Medicine, Boston City Hospital, and Boston University Medical School, Boston
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Virginia R. Farrell
Virginia R. Farrell
From the Departments of Medicine, Peter Bent Brigham Hospital, and Harvard University Medical School, and the Departments of Medicine, Boston City Hospital, and Boston University Medical School, Boston
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Author and Article Information
Leon R. Cole
From the Departments of Medicine, Peter Bent Brigham Hospital, and Harvard University Medical School, and the Departments of Medicine, Boston City Hospital, and Boston University Medical School, Boston
J. Jay Matloff
From the Departments of Medicine, Peter Bent Brigham Hospital, and Harvard University Medical School, and the Departments of Medicine, Boston City Hospital, and Boston University Medical School, Boston
Virginia R. Farrell
From the Departments of Medicine, Peter Bent Brigham Hospital, and Harvard University Medical School, and the Departments of Medicine, Boston City Hospital, and Boston University Medical School, Boston
Received: August 03 1955
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1955, by The Rockefeller Institute for Medical Research New York
1955
J Exp Med (1955) 102 (6): 647–653.
https://doi.org/10.1084/jem.102.6.647
Article history
Received:
August 03 1955

A serological technique, using formalinized red cells coupled to tuberculin PPD as antigen, has been assayed in a trial series of 124 tuberculous and 139 non-tuberculous patients. The stability of the antigen preparation, and the omission of an adsorption procedure for the removal of isoagglutinins facilitated the performance of the test. The results indicate that the technique warrants further trial as a diagnostic criterion of infection tuberculosis.

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Copyright, 1955, by The Rockefeller Institute for Medical Research New York
1955
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