The alterations in succinic dehydrogenase activity during the course of infection with Mycobacterium tuberculosis strains H37Rv and BCG, as well as with dead bacilli, has been described. A tissue factor has been described which is prepared from normal bovine kidney and will restore enzyme activity in vitro. This factor is prepared by chromatographic analysis and contains a nucleotide with an ultraviolet absorption maxima at 250 mµ (pH 3) and a free sulfhydryl group. The role of this factor in the response to tuberculosis is discussed.
A TISSUE FACTOR INFLUENCING SUCCINIC DEHYDROGENASE ACTIVITY IN TUBERCULOUS GUINEA PIGS
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S. P. Martin, C. D. Cooper, S. N. Chaudhuri, R. Green; A TISSUE FACTOR INFLUENCING SUCCINIC DEHYDROGENASE ACTIVITY IN TUBERCULOUS GUINEA PIGS . J Exp Med 1 June 1955; 101 (6): 639–646. doi: https://doi.org/10.1084/jem.101.6.639
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