1. The removal of one half, two thirds and sometimes three quarters of the kidney substance in the dog causes no change in the general nitrogenous metabolism as determined by estimations of the total nitrogen, urea and ammonia elimination by the urine.
2. The removal of larger amounts, and sometimes of three quarters of the substance, leads to the metabolism condition of starvation. This, however, is apparently the result of the gastro-intestinal disturbance constantly associated with extensive kidney reduction and not of a disturbance of general nitrogenous metabolism.
3. The determination of the amount of fæcal nitrogen indicates that the gastro-intestinal disturbance is not due to diminished absorption; and except in one instance there was no evidence of its being due to an increased elimination of nitrogenous substances into the intestine.
4. These experiments do not support the theory that the kidney furnishes an internal secretion having an important influence on general nitrogenous metabolism. At least, if such a function exists, it is not disturbed by the removal of three quarters of the kidney substance.
5. The metabolism in excessive kidney reduction is that of inanition dependent on gastro-intestinal disturbances presumably due to faulty chemical correlation. In this connection further knowledge concerning the elimination into the intestine of toxic substances is desirable.