1. The nodules found in the spleen are islands of active hæmatoplastic tissue.
2. The bone-marrow, at least in the case which has been described, has been the primary focus of disease; some toxin has probably produced a chronic inflammatory change.
3. The bone-marrow, owing to its enormous sclerosis, has lost its hæmopoëtic powers totally or to a marked degree and the spleen has reverted to its fœtal power to form blood.