Focal myocardial necrosis that was often extensive was found in a high percentage of rabbits, guinea pigs, and mice given a single intravenous injection of crystalline streptococcal proteinase.

The findings are discussed in relation to their possible implications for the pathogenesis of the cardiac lesions of rheumatic fever.

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Copyright, 1954, by The Rockefeller Institute for Medical Research New York
1954
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