The IgM antibody response to Type III pneumococcal polysaccharide (SSS-III) was assessed in F1, F2, and backcross progeny derived from high (BALB/cAnN) and extremely low (CBA/HN) responding parental strains of inbred mice. The results of these studies indicated that a major component involved in the antibody response is X-linked, i.e., carried on the X chromosome; this component determines responsiveness to SSS-III in an almost quantal or "all-or-none" manner. Other factors, presumably autosomal genes, regulate the magnitude of the antibody response produced by mice possessing the X-linked gene; these appear to influence independently the number of antibody-producing cells found after immunization and the amount of antibody made by such cells. Strains of inbred mice varied widely in their ability to respond to SSS-III. Responsiveness was not associated with H-2 histocompatibility type. The implications of these findings with respect to the genetic control of the antibody response to SSS-III are discussed.
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1 October 1972
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October 01 1972
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE : I. EVIDENCE THAT AN X-LINKED GENE PLAYS A DECISIVE ROLE IN DETERMINING RESPONSIVENESS
Diana F. Amsbaugh,
Diana F. Amsbaugh
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Carl T. Hansen,
Carl T. Hansen
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Benjamin Prescott,
Benjamin Prescott
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Philip W. Stashak,
Philip W. Stashak
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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David R. Barthold,
David R. Barthold
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Phillip J. Baker
Phillip J. Baker
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
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Diana F. Amsbaugh
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Carl T. Hansen
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Benjamin Prescott
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Philip W. Stashak
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
David R. Barthold
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Phillip J. Baker
From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014
Received:
May 26 1972
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1972 by The Rockefeller University Press
1972
J Exp Med (1972) 136 (4): 931–949.
Article history
Received:
May 26 1972
Citation
Diana F. Amsbaugh, Carl T. Hansen, Benjamin Prescott, Philip W. Stashak, David R. Barthold, Phillip J. Baker; GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE : I. EVIDENCE THAT AN X-LINKED GENE PLAYS A DECISIVE ROLE IN DETERMINING RESPONSIVENESS . J Exp Med 1 October 1972; 136 (4): 931–949. doi: https://doi.org/10.1084/jem.136.4.931
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