STUDIES OF PPLO INFECTION III. ELECTRON MICROSCOPIC STUDY OF BRAIN LESIONS CAUSED BY MYCOPLASMA NEUROLYTICUM TOXIN

Aleu , Fernando; Thomas , Lewis

doi:10.1084/jem.124.6.1083

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Article| December 01 1966

STUDIES OF PPLO INFECTION : III. ELECTRON MICROSCOPIC STUDY OF BRAIN LESIONS CAUSED BY MYCOPLASMA NEUROLYTICUM TOXIN

Fernando Aleu,

Fernando Aleu

From the Departments of Neurology and Medicine, New York University School of Medicine, and the Laboratory of Neuropathology of the Office of the Chief Medical Examiner of New York City

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Lewis Thomas

From the Departments of Neurology and Medicine, New York University School of Medicine, and the Laboratory of Neuropathology of the Office of the Chief Medical Examiner of New York City

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Author and Article Information

Fernando Aleu

From the Departments of Neurology and Medicine, New York University School of Medicine, and the Laboratory of Neuropathology of the Office of the Chief Medical Examiner of New York City

Lewis Thomas

From the Departments of Neurology and Medicine, New York University School of Medicine, and the Laboratory of Neuropathology of the Office of the Chief Medical Examiner of New York City

Received: June 27 1966

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1966

J Exp Med (1966) 124 (6): 1083–1088.

https://doi.org/10.1084/jem.124.6.1083

The ultrastructure of the experimental encephalopathy caused by Mycoplasma neurolyticum toxin has been studied. The primary changes are (a) massive distention of astrocytes by fluid, associated with degenerative changes in these cells, (b) mechanical displacement and compression of myelinated axons by swollen astrocytic processes, (c) the appearance of free, extracellular fluid in the white matter, and (d) early primary myelin degeneration without damage to axons.

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1966

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STUDIES OF PPLO INFECTION : III. ELECTRON MICROSCOPIC STUDY OF BRAIN LESIONS CAUSED BY MYCOPLASMA NEUROLYTICUM TOXIN

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