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Volume 116, Issue 2
1 August 1962
Journal of Experimental Medicine Cover Image for Volume 116, Issue 2
Article| August 01 1962

ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS : II. SUPPRESSIVE EFFECT OF THYMECTOMY AT BIRTH ON REACTIONS OF DELAYED (CELLULAR) HYPERSENSITIVITY AND THE CIRCULATING SMALL LYMPHOCYTE

Barry G. Arnason,
Barry G. Arnason
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
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Branislav D. Janković,
Branislav D. Janković
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
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Byron H. Waksman,
Byron H. Waksman
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
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Christine Wennersten
Christine Wennersten
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
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Author and Article Information
Barry G. Arnason
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
Branislav D. Janković
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
Byron H. Waksman
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
Christine Wennersten
From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston
Received: April 10 1962
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1962, by The Rockefeller Institute
1962
J Exp Med (1962) 116 (2): 177–186.
https://doi.org/10.1084/jem.116.2.177
Article history
Received:
April 10 1962

In rats thymectomized at birth and tested in adult life, ability to develop autoallergic encephalomyelitis was completely suppressed, there was a marked diminution in the degree of tuberculin sensitization appearing after a single injection of mycobacteria in oil, rejection of skin homografts was markedly delayed, and adjuvant arthritis was not appreciably affected. At the same time there was a striking decrease in the circulating level of small lymphocytes.

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Copyright, 1962, by The Rockefeller Institute
1962
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