THE INFLUENCE OF DIET ON IRON ABSORPTION I. THE PATHOLOGY OF IRON EXCESS

Kinney , Thomas D.; Hegsted , D. Mark; Finch , Clement A.

doi:10.1084/jem.90.2.137

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Article| August 01 1949

THE INFLUENCE OF DIET ON IRON ABSORPTION : I. THE PATHOLOGY OF IRON EXCESS

Thomas D. Kinney,

Thomas D. Kinney

From the Departments of Pathology, Biological Chemistry, and Medicine, Harvard Medical School, the Department of Nutrition, Harvard School of Public Health; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

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D. Mark Hegsted,

D. Mark Hegsted

From the Departments of Pathology, Biological Chemistry, and Medicine, Harvard Medical School, the Department of Nutrition, Harvard School of Public Health; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

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Clement A. Finch

From the Departments of Pathology, Biological Chemistry, and Medicine, Harvard Medical School, the Department of Nutrition, Harvard School of Public Health; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

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Author and Article Information

Thomas D. Kinney

From the Departments of Pathology, Biological Chemistry, and Medicine, Harvard Medical School, the Department of Nutrition, Harvard School of Public Health; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

D. Mark Hegsted

From the Departments of Pathology, Biological Chemistry, and Medicine, Harvard Medical School, the Department of Nutrition, Harvard School of Public Health; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

Clement A. Finch

From the Departments of Pathology, Biological Chemistry, and Medicine, Harvard Medical School, the Department of Nutrition, Harvard School of Public Health; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

Received: January 30 1949

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1949, by The Rockefeller Institute for Medical Research New York

1949

J Exp Med (1949) 90 (2): 137–146.

https://doi.org/10.1084/jem.90.2.137

Rats placed on a corn grit diet and added iron absorbed large amounts of iron in contrast to control groups.

The histological picture was that of progressive hemosiderosis of the hepatic parenchyma and of the reticuloendothelial system. On chemical analysis, the iron content of the liver was found to be greatly increased. This supports the concept that the liver represents the chief storage organ for iron so absorbed.

These data indicate that a normal block for iron absorption may be overcome under certain circumstances.

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Copyright, 1949, by The Rockefeller Institute for Medical Research New York

1949

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