OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE

Loeb , Emily N.; Knowlton , Abbie I.; Stoerk , Herbert C.; Seegal , Beatrice C.

doi:10.1084/jem.89.3.287

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Article| March 01 1949

OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE

Emily N. Loeb,

Emily N. Loeb

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

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Abbie I. Knowlton,

Abbie I. Knowlton

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

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Herbert C. Stoerk,

Herbert C. Stoerk

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

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Beatrice C. Seegal

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

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Author and Article Information

Emily N. Loeb

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

Abbie I. Knowlton

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

Herbert C. Stoerk

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

Beatrice C. Seegal

From the Departments of Medicine and of Bacteriology, College of Physicians and Surgeons, Columbia University, New York, and the Merck Institute for Therapeutic Research, Rahway

Received: November 18 1948

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1949, by The Rockefeller Institute for Medical Research New York

1949

J Exp Med (1949) 89 (3): 287–293.

https://doi.org/10.1084/jem.89.3.287

1. Pregnancy enhances the susceptibility of the rat to intercurrent renal damage produced by anti-placenta serum. This is manifested by the development of renal hypertrophy and nephritis in a number of these animals. Both renal hypertrophy and nephritis are consistently intensified by the concomitant administration of DCA.

2. Hypertension develops in both pregnant and non-pregnant rats treated with the anti-placenta serum employed together with the daily administration of DCA.

3. Termination of pregnancy, in the face of continued DCA administration, fails to lower the blood pressure or to arrest the nephritic process.

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Copyright, 1949, by The Rockefeller Institute for Medical Research New York

1949

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OBSERVATIONS ON THE PREGNANT RAT INJECTED WITH NEPHROTOXIC RABBIT ANTI-RAT PLACENTA SERUM AND DESOXYCORTICOSTERONE ACETATE

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