ANTIBODY FORMATION IN MEN FOLLOWING INJECTION OF FOUR TYPE-SPECIFIC POLYSACCHARIDES OF PNEUMOCOCCUS

Heidelberger , Michael; MacLeod , Colin M.; Hodges , Richard G.; Bernhard , William G.; di Lapi , Marie M.

doi:10.1084/jem.85.3.227

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Article| March 01 1947

ANTIBODY FORMATION IN MEN FOLLOWING INJECTION OF FOUR TYPE-SPECIFIC POLYSACCHARIDES OF PNEUMOCOCCUS

Michael Heidelberger,

Michael Heidelberger

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

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Colin M. MacLeod,

Colin M. MacLeod

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

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Richard G. Hodges,

Richard G. Hodges

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

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William G. Bernhard,

William G. Bernhard

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

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Marie M. di Lapi

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

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Author and Article Information

Michael Heidelberger

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

Colin M. MacLeod

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

Richard G. Hodges

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

William G. Bernhard

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

Marie M. di Lapi

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, the Department of Bacteriology, New York University College of Medicine, New York, and the Army Air Force Rheumatic Fever Laboratory, Sioux Falls

Received: November 18 1946

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1947, by The Rockefeller Institute for Medical Research New York

1947

J Exp Med (1947) 85 (3): 227–230.

https://doi.org/10.1084/jem.85.3.227

1. Random selections of the sera of trainees injected 2 months previously with the specific polysaccharides of Types I, II, V, and VII pneumococci contained quantities of antibody to Types I, II, and VII sufficient to account for the favorable results of the immunization procedure.

2. As in earlier studies, the levels of the antibody for the C polysaccharide remained relatively constant before and after the injections.

3. The serum from the preliminary bleedings often contained antibody to the Type VII polysaccharide. This remained relatively constant in a control group injected with saline.

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Copyright, 1947, by The Rockefeller Institute for Medical Research New York

1947

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