STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA III. FACTORS INFLUENCING THE PHAGOCYTOSIS OF PNEUMOCOCCI IN THE LUNG DURING SULFONAMIDE THERAPY

Wood , W. Barry; McLeod , Charlotte; Irons , Edwin N.

doi:10.1084/jem.84.4.377

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Article| October 01 1946

STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : III. FACTORS INFLUENCING THE PHAGOCYTOSIS OF PNEUMOCOCCI IN THE LUNG DURING SULFONAMIDE THERAPY

W. Barry Wood, Jr.,

W. Barry Wood, Jr.

From the Department of Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, St. Louis, and the Departmert of Medicine, Johns Hopkins University School of Medicine, Baltimore

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Charlotte McLeod,

Charlotte McLeod

From the Department of Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, St. Louis, and the Departmert of Medicine, Johns Hopkins University School of Medicine, Baltimore

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Edwin N. Irons

From the Department of Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, St. Louis, and the Departmert of Medicine, Johns Hopkins University School of Medicine, Baltimore

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Author and Article Information

W. Barry Wood, Jr.

From the Department of Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, St. Louis, and the Departmert of Medicine, Johns Hopkins University School of Medicine, Baltimore

Charlotte McLeod

From the Department of Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, St. Louis, and the Departmert of Medicine, Johns Hopkins University School of Medicine, Baltimore

Edwin N. Irons

From the Department of Medicine, Washington University School of Medicine, and the Oscar Johnson Institute for Medical Research, St. Louis, and the Departmert of Medicine, Johns Hopkins University School of Medicine, Baltimore

Received: June 09 1946

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1946, by The Rockefeller Institute for Medical Research New York

1946

J Exp Med (1946) 84 (4): 377–386.

https://doi.org/10.1084/jem.84.4.377

The phagocytosis which occurs in the lungs of rats receiving sulfonamide is due neither to an opsonizing action of the sulfonamides nor to type-specific antibody. The evidence presented indicates that the destruction of the pneumococci is brought about by a phagocytic mechanism independent of both opsonization and capsular injury.

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Copyright, 1946, by The Rockefeller Institute for Medical Research New York

1946

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STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : III. FACTORS INFLUENCING THE PHAGOCYTOSIS OF PNEUMOCOCCI IN THE LUNG DURING SULFONAMIDE THERAPY

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