STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES II. EFFECT OF DESOXYRIBONUCLEASE ON THE BIOLOGICAL ACTIVITY OF THE TRANSFORMING SUBSTANCE

McCarty , Maclyn; Avery , Oswald T.

doi:10.1084/jem.83.2.89

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Article| February 01 1946

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES : II. EFFECT OF DESOXYRIBONUCLEASE ON THE BIOLOGICAL ACTIVITY OF THE TRANSFORMING SUBSTANCE

Maclyn McCarty,

Maclyn McCarty

From the United States Navy Research Unit at the Hospital of The Rockefeller Institute for Medical Research

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Oswald T. Avery

From the United States Navy Research Unit at the Hospital of The Rockefeller Institute for Medical Research

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Author and Article Information

Maclyn McCarty

From the United States Navy Research Unit at the Hospital of The Rockefeller Institute for Medical Research

Oswald T. Avery

From the United States Navy Research Unit at the Hospital of The Rockefeller Institute for Medical Research

Received: October 09 1945

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1946, by The Rockefeller Institute for Medical Research New York

1946

J Exp Med (1946) 83 (2): 89–96.

https://doi.org/10.1084/jem.83.2.89

It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance of Pneumococcus Type III. The significance of the effect of the enzyme, and its bearing on the chemical nature of the transforming substance, together with certain considerations concerning the biological specificity of desoxyribonucleic acids in general, are discussed.

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Copyright, 1946, by The Rockefeller Institute for Medical Research New York

1946

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STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES : II. EFFECT OF DESOXYRIBONUCLEASE ON THE BIOLOGICAL ACTIVITY OF THE TRANSFORMING SUBSTANCE

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