A study has been made to establish the statistical significance of results obtained in mouse infectivity titrations of influenza virus. Five titrations, each composed of five replicas, were carried out and 50 per cent end points were calculated for each titration. Three criteria for evaluating the end points were employed, namely, the presence or absence of pulmonary lesions, the occurrence of death, and a weighted composite taking into account both the extent of lung consolidation and the occurrence of death. Standard deviations of the distribution of end points obtained by each method were computed, and from these data levels of probabilities for significance in the differences between end points were determined. It was found that the chances are 19 out of 20 that differences of 0.99, 0.77, and 0.73 logarithmic units, respectively, for the lesion, the death, and the weighted end points are significant.
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1 February 1944
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February 01 1944
THE MOUSE INFECTIVITY TITRATION OF INFLUENZA VIRUS
Max A. Lauffer,
Max A. Lauffer
From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey
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Gail Lorenz Miller
Gail Lorenz Miller
From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey
Search for other works by this author on:
Max A. Lauffer
From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey
Gail Lorenz Miller
From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey
Received:
November 03 1943
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1944, by The Rockefeller Institute for Medical Research New York
1944
J Exp Med (1944) 79 (2): 197–203.
Article history
Received:
November 03 1943
Citation
Max A. Lauffer, Gail Lorenz Miller; THE MOUSE INFECTIVITY TITRATION OF INFLUENZA VIRUS . J Exp Med 1 February 1944; 79 (2): 197–203. doi: https://doi.org/10.1084/jem.79.2.197
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