CHANGES IN LIPID CONTENT OF SERUM AND OF LIVER FOLLOWING BILATERAL RENAL ABLATION OR URETERAL LIGATION

Winkler , A. W.; Durlacher , S. H.; Hoff , H. E.; Man , E. B.

doi:10.1084/jem.77.5.473

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Article| May 01 1943

CHANGES IN LIPID CONTENT OF SERUM AND OF LIVER FOLLOWING BILATERAL RENAL ABLATION OR URETERAL LIGATION

A. W. Winkler,

A. W. Winkler

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

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S. H. Durlacher,

S. H. Durlacher

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

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H. E. Hoff,

H. E. Hoff

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

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E. B. Man

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

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Author and Article Information

A. W. Winkler

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

S. H. Durlacher

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

H. E. Hoff

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

E. B. Man

From the Departments of Medicine, of Pathology, of Physiology, and of Psychiatry, Yale University School of Medicine, New Haven

Received: March 04 1943

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1943, by The Rockefeller Institute for Medical Research New York

1943

J Exp Med (1943) 77 (5): 473–486.

https://doi.org/10.1084/jem.77.5.473

1. In the dog and monkey bilateral nephrectomy or ureteral ligation results in a marked, progressive increase of total fatty acids, of free and esterified cholesterol, of phospholipid, and of free fat of serum.

2. No such changes follow unilateral nephrectomy, splenectomy, or fasting.

3. The increase after bilateral nephrectomy is not inhibited by glucose administration.

4. A marked increase of the phospholipid and a less significant elevation in cholesterol content of the liver accompanies this increase of serum lipids after bilateral nephrectomy.

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Copyright, 1943, by The Rockefeller Institute for Medical Research New York

1943

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CHANGES IN LIPID CONTENT OF SERUM AND OF LIVER FOLLOWING BILATERAL RENAL ABLATION OR URETERAL LIGATION

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