LIVER DAMAGE AND URINARY EXCRETION OF SULFATE IN RATS FED l-CYSTINE, dl-METHIONINE, AND CYSTEIC ACID

Earle , David P.; Kendall , Forrest E.

doi:10.1084/jem.75.2.191

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Article| February 01 1942

LIVER DAMAGE AND URINARY EXCRETION OF SULFATE IN RATS FED l-CYSTINE, dl-METHIONINE, AND CYSTEIC ACID

David P. Earle, Jr.,

David P. Earle, Jr.

From the Research Service, First Division, Welfare Hospital, Department of Hospitals, City of New York, and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York

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Forrest E. Kendall

From the Research Service, First Division, Welfare Hospital, Department of Hospitals, City of New York, and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York

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Author and Article Information

David P. Earle, Jr.

From the Research Service, First Division, Welfare Hospital, Department of Hospitals, City of New York, and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York

Forrest E. Kendall

From the Research Service, First Division, Welfare Hospital, Department of Hospitals, City of New York, and the Department of Medicine, College of Physicians and Surgeons, Columbia University, New York

Received: October 31 1941

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1942, by The Rockefeller Institute for Medical Research New York

1942

J Exp Med (1942) 75 (2): 191–195.

https://doi.org/10.1084/jem.75.2.191

1. Rats fed l-cystine at excessive levels excrete large amounts of sulfate sulfur in the urine and develop liver necrosis and cirrhosis.

2. Rats fed dl-methionine at excessive levels excrete large amounts of sulfate sulfur, but do not develop liver necrosis and cirrhosis.

3. Rats fed cysteic acid at high levels excrete relatively small amounts of sulfate, but do develop liver necrosis and cirrhosis.

4. In conclusion, there is no apparent correlation between the amount of sulfate formed and the development of liver damage in rats fed l-cystine, dl-methionine, and cysteic acids.

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Copyright, 1942, by The Rockefeller Institute for Medical Research New York

1942

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