In normal male dogs subcutaneous injections of progesterone, estrone, α-estradiol or testosterone propionate were followed by a decreased renal excretion of sodium and chloride. The compounds differed markedly in their potency and in the duration of the effect following a single subcutaneous injection. The injection of estrone, α-estradiol or testosterone propionate was followed by a decreased renal excretion of inorganic phosphorus and total nitrogen. On the day of injection a slight increase in the renal excretion of potassium frequently followed administration of progesterone, estrone, α-estradiol or testosterone propionate. Experiments on suprarenalectomized dogs indicated that the effect of the sex hormones on the renal excretion of electrolytes was not necessarily mediated through the suprarenal gland. With the possible exception of progesterone none of the compounds studied was effective in prolonging the life of suprarenalectomized male dogs.
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1 September 1938
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September 01 1938
THE EFFECT OF SEX HORMONES ON THE RENAL EXCRETION OF ELECTROLYTES
George W. Thorn,
George W. Thorn
From the Chemical Division, Medical Clinic, Johns Hopkins University and Hospital, Baltimore
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Lewis L. Engel
Lewis L. Engel
From the Chemical Division, Medical Clinic, Johns Hopkins University and Hospital, Baltimore
Search for other works by this author on:
George W. Thorn
From the Chemical Division, Medical Clinic, Johns Hopkins University and Hospital, Baltimore
Lewis L. Engel
From the Chemical Division, Medical Clinic, Johns Hopkins University and Hospital, Baltimore
Received:
June 08 1938
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1938, by The Rockefeller Institute for Medical Research New York
1938
J Exp Med (1938) 68 (3): 299–312.
Article history
Received:
June 08 1938
Citation
George W. Thorn, Lewis L. Engel; THE EFFECT OF SEX HORMONES ON THE RENAL EXCRETION OF ELECTROLYTES . J Exp Med 1 September 1938; 68 (3): 299–312. doi: https://doi.org/10.1084/jem.68.3.299
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