1. Perfusion of isolated thyroid glands from rabbits, made refractory to the action of the thyro-stimulating factor from the hypophysis by repeated injections for 2 months, has shown that in this condition the thyroid epithelium responds to pituitary stimulation.
2. The serum from refractory rabbits does not neutralize completely the thyro-stimulating effect of anterior pituitary extract upon an isolated normal thyroid gland.
3. It is believed that tissues other than the thyroid play a rôle in bringing about the phenomena which have been described as refractoriness against a prolonged action of the thyro-stimulating pituitary factor.
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Copyright, 1937, by The Rockefeller Institute for Medical Research New York
1937
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