Experimental study of the rabbit papilloma of Shope, a growth caused by a virus, has shown that it possesses the immediate characters whereby tumors are recognized. Often it looks and acts like a malignant neoplasm. It differs from the tumors as a group, however, in its incidence which is that of an infectious process, and from other mammalian tumors in that its cause has been demonstrated. The possible bearing of the findings upon the problem of tumor causation is discussed. The morphology and behavior of the generality of tumors can no longer be taken to exclude the possibility that these are produced by extraneous, living entities. The incidence of some of the tumors at least, and the failure to demonstrate their cause can both be explained on the assumption that they are due to such entities, widely distributed in or upon the animal population but effective only under special circumstances. Present knowledge makes this assumption reasonable as a basis for further work.
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1 December 1934
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December 01 1934
A VIRUS-INDUCED MAMMALIAN GROWTH WITH THE CHARACTERS OF A TUMOR (THE SHOPE RABBIT PAPILLOMA) : III. FURTHER CHARACTERS OF THE GROWTH: GENERAL DISCUSSION
Peyton Rous,
Peyton Rous
From the Laboratories of The Rockefeller Institute for Medical Research
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J. W. Beard
J. W. Beard
From the Laboratories of The Rockefeller Institute for Medical Research
Search for other works by this author on:
Peyton Rous
From the Laboratories of The Rockefeller Institute for Medical Research
J. W. Beard
From the Laboratories of The Rockefeller Institute for Medical Research
Received:
August 08 1934
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1934, by The Rockefeller Institute for Medical Research New York
1934
J Exp Med (1934) 60 (6): 741–766.
Article history
Received:
August 08 1934
Citation
Peyton Rous, J. W. Beard; A VIRUS-INDUCED MAMMALIAN GROWTH WITH THE CHARACTERS OF A TUMOR (THE SHOPE RABBIT PAPILLOMA) : III. FURTHER CHARACTERS OF THE GROWTH: GENERAL DISCUSSION . J Exp Med 1 December 1934; 60 (6): 741–766. doi: https://doi.org/10.1084/jem.60.6.741
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