STUDIES ON THE SHWARTZMAN PHENOMENON I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES

Klein , Herbert M.

doi:10.1084/jem.56.4.587

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Article| October 01 1932

STUDIES ON THE SHWARTZMAN PHENOMENON : I. DETOXIFICATION OF MENINGOCOCCUS CULTURE FILTRATES

Herbert M. Klein

From the Laboratories of The Mount Sinai Hospital, New York

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Author and Article Information

Herbert M. Klein

From the Laboratories of The Mount Sinai Hospital, New York

Received: June 17 1932

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1932, by The Rockefeller Institute for Medical Research New York

1932

J Exp Med (1932) 56 (4): 587–600.

https://doi.org/10.1084/jem.56.4.587

Formalin induces a considerable change in meningococcus culture filtrates. This consists of a marked decrease in toxidty as concerns both the Shwartzman phenomenon and the lethal effect, with relative preservation of the antibody-combining capacity and antigenicity.

A similar modification occurs spontaneously in meningococcus culture filtrates on standing.

Inasmuch as these changes parallel those occurring in the conversion of diphtheria toxin into toxoid, it is justifiable to consider such altered meningococcus toxin as meningococcus toxoid.

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Copyright, 1932, by The Rockefeller Institute for Medical Research New York

1932

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