THE FATE OF ORALLY ADMINISTERED SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS TYPES I, II AND III

Ross , Victor

doi:10.1084/jem.55.1.13

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Article| January 01 1932

THE FATE OF ORALLY ADMINISTERED SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS TYPES I, II AND III

Victor Ross

From the Department of Biological Chemistry, College of Physicians and Surgeons, Columbia University, and the Bureau of Laboratories, Department of Health of the City of New York, New York

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Victor Ross

From the Department of Biological Chemistry, College of Physicians and Surgeons, Columbia University, and the Bureau of Laboratories, Department of Health of the City of New York, New York

Received: July 28 1931

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1932, by The Rockefeller Institute for Medical Research New York

1932

J Exp Med (1932) 55 (1): 13–25.

https://doi.org/10.1084/jem.55.1.13

1. Rats, when fed the soluble specific substance of Types I, II and III pneumococcus, excrete a very large proportion in the feces.

2. Following ingestion of these substances, tests sensitive enough to detect 1 part in 2,000,000 of serum, and 1 part in 3,000,000 of urine, were negative.

3. The polysaccharide of Type I, when recovered from the feces, is as active an immunizing agent as it was originally.

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Copyright, 1932, by The Rockefeller Institute for Medical Research New York

1932

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