STUDIES ON THE RELATIONSHIP OF THE CHEMICAL CONSTITUENTS OF BLOOD AND CEREBROSPINAL FLUID

Kubie , Lawrence S.; Shults , Gertrude M.

doi:10.1084/jem.42.4.565

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Article| October 01 1925

STUDIES ON THE RELATIONSHIP OF THE CHEMICAL CONSTITUENTS OF BLOOD AND CEREBROSPINAL FLUID

Lawrence S. Kubie,

Lawrence S. Kubie

From the Department of Physiology of the Johns Hopkins Medical School and the Laboratory of Internal Medicine of the Henry Phipps Psychiatric Clinic of the Johns Hopkins Hospital, Baltimore.

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Gertrude M. Shults

From the Department of Physiology of the Johns Hopkins Medical School and the Laboratory of Internal Medicine of the Henry Phipps Psychiatric Clinic of the Johns Hopkins Hospital, Baltimore.

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Author and Article Information

Lawrence S. Kubie

From the Department of Physiology of the Johns Hopkins Medical School and the Laboratory of Internal Medicine of the Henry Phipps Psychiatric Clinic of the Johns Hopkins Hospital, Baltimore.

Gertrude M. Shults

From the Department of Physiology of the Johns Hopkins Medical School and the Laboratory of Internal Medicine of the Henry Phipps Psychiatric Clinic of the Johns Hopkins Hospital, Baltimore.

Received: June 21 1925

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1925, by The Rockefeller Institute for Medical Research New York

1925

J Exp Med (1925) 42 (4): 565–591.

https://doi.org/10.1084/jem.42.4.565

1. If due allowance is made for the slow rate of elaboration of cerebrospinal fluid and for the time that it takes for newly formed fluid to emerge from a needle in the cistema, the amount of sugar, chloride, and non-protein nitrogen in the fluid seems to follow in a general way their concentrations in the blood stream.

2. It is equally evident, however, that for any substance other factors besides its concentration in the blood stream play a part in its distribution between blood and cerebrospinal fluid.

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Copyright, 1925, by The Rockefeller Institute for Medical Research New York

1925

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