THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE II. THE TOXIC EFFECT OF KILLED BACTERIA IN ADRENALECTOMIZED RATS.

Scott , W. J. M.

doi:10.1084/jem.39.3.457

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Article| March 01 1924

THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE : II. THE TOXIC EFFECT OF KILLED BACTERIA IN ADRENALECTOMIZED RATS.

W. J. M. Scott

From the Laboratory of Surgical Research of Harvard Medical School, Boston.

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Author and Article Information

W. J. M. Scott

From the Laboratory of Surgical Research of Harvard Medical School, Boston.

Received: October 10 1923

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1924, by The Rockefeller Institute for Medical Research New York

1924

J Exp Med (1924) 39 (3): 457–471.

https://doi.org/10.1084/jem.39.3.457

1. The resistance of rats to bacterial intoxication is greatly decreased after double adrenalectomy.

2. This decreased resistance is dependent upon a functional insufficiency of the adrenal cortex.

3. A dose of killed streptococci or staphylococci can be obtained that is invariably fatal to adrenalectomized rats, before hypertrophy of cortical accessories, but never kills control rats.

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Copyright, 1924, by The Rockefeller Institute for Medical Research New York

1924

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THE INFLUENCE OF THE ADRENAL GLANDS ON RESISTANCE : II. THE TOXIC EFFECT OF KILLED BACTERIA IN ADRENALECTOMIZED RATS.

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