The picture is one of a true diabetes mellitus, first attracting attention after miscarriage. Although the G : N ratio sank from 3 : 1 on 10 gm. of nitrogen to 1.7 : 1 after 3 days' fasting, the disease progressed steadily in spite of a long continued carbohydrate-free diet. Together with the usual complications of diabetes, a malignant tumor of the thymus developed, so that after 5 months' observations a slow death was forestalled by chloroform. The most striking feature at autopsy was the large, apparently normal pancreas, which exhibited histologically marked changes in the islands of Langerhans, extreme hydropic degeneration and exhaustion of granules, involving both alpha and beta cells, but especially the latter, and replacement of some islands by fibrous tissue.
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1 October 1916
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October 01 1916
SPONTANEOUS DIABETES IN A DOG
Edward B. Krumbhaar
Edward B. Krumbhaar
From the John Herr Musser Department of Research Medicine of the University of Pennsylvania, Philadelphia.
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Edward B. Krumbhaar
From the John Herr Musser Department of Research Medicine of the University of Pennsylvania, Philadelphia.
Received:
June 21 1916
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1916, by The Rockefeller Institute for Medical Research New York
1916
J Exp Med (1916) 24 (4): 361–365.
Article history
Received:
June 21 1916
Citation
Edward B. Krumbhaar; SPONTANEOUS DIABETES IN A DOG . J Exp Med 1 October 1916; 24 (4): 361–365. doi: https://doi.org/10.1084/jem.24.4.361
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