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Volume 203, Issue 4
17 April 2006
Journal of Experimental Medicine Cover Image for Volume 203, Issue 4
Article Contents
Commentary| April 10 2006

Helper T cell differentiation enters a new era: Le Roi est mort; vive le Roi!

Cristina M. Tato,
Cristina M. Tato
C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
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Arian Laurence,
Arian Laurence
C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
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John J. O'Shea
John J. O'Shea
C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
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Author and Article Information
Cristina M. Tato
C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Arian Laurence
C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
John J. O'Shea
C.M.T., A.L., and J.J.O. are at Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
CORRESPONDENCE C.M.T: [email protected]
Online ISSN: 1540-9538
Print ISSN: 0022-1007
The Rockefeller University Press
2006
J Exp Med (2006) 203 (4): 809–812.
https://doi.org/10.1084/jem.20060522
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Related Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17–related cytokine IL-25 is essential for Th2 responses in two infectious disease models.

The Rockefeller University Press
2006
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